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Cobimetinib Fumarate

What is Cotellic?
Cotellic (cobimetinib) is a cancer drug that prevents cancer cells from growing and spreading in the body.
Cotellic is a drug that is used to treat a type of metastatic melanoma (skin cancer) that has spread to other places of the body and is resistant to surgery.


Follow the directions on the label and container of your drug. All of your medical conditions, allergies, and medications should be disclosed to each of your healthcare providers.

Before taking this medicine

If you are allergic to cobimetinib, you should not use Cotellic.

To make sure Cotellic is safe for you, tell your doctor if you have:

a history of eye difficulties (particularly a problem with your retina); liver or renal disease; skin problems not connected to melanoma; a muscular disorder; a bleeding or blood clotting disorder such as hemophilia; or a condition that requires the use of a blood thinner such as warfarin (Coumadin, Jantoven).

How should I take Cotellic?
Follow your doctor’s instructions for taking Cotellic. Blood tests will be performed by your doctor to ensure that you have the correct tumor type for cobimetinib treatment.

Cotellic side effects

If you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, seek emergency medical attention right away.

Stop using Cotellic and call your doctor at once if you have:

Unexplained muscle pain, tenderness, or weakness (particularly if you also have a fever and dark-colored urine); visual changes, partial vision loss, seeing halos around lights; unexplained muscle pain, tenderness, or weakness (especially if you also have a fever and dark-colored urine);
bruising or bleeding that is easy to come by (nosebleeds, bleeding gums);
Weakness, dizziness, headache, red or pink urine, bloody or tarry stools, spitting up blood or vomit that looks like coffee grounds are all indicators of internal bleeding.
Cough, wheezing, shortness of breath (even with modest exercise), chest pain, fast heartbeats, swelling in your feet or ankles are all indicators of a heart condition.
Low sodium levels in the body cause headaches, slurred speech, extreme weakness, vomiting, lack of coordination, and unsteadiness.
Nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored feces, jaundice (yellowing of the skin or eyes) are all symptoms of liver disease.
Skin rash that spreads and causes blistering and peeling, as well as skin pain, itching, redness, lumps or pimples, thickened or wrinkled skin, and skin rash that causes blistering and peeling.

Common Cotellic side effects may include:

Nausea, vomiting, and diarrhea; fever; sunburn or increased susceptibility to sunlight; low sodium levels; or abnormal laboratory tests are all possible symptoms.


This is not an exhaustive list of potential adverse effects; more may arise. For medical advice on side effects, contact your doctor.


HoneyBee Pharmacy offers best priced* guaranteed. Although HoneyBee Pharmacy is not covered by Medicare, HoneyBee Pharmacy offers medical expense reports that you may submit to your local insurance companies. Should you be reimbursed that is separate from us. HoneyBee Pharmacy also offers best priced* guaranteed for all medications for more information simply give us a call at 1-888-557-0340.

ATTENTION REQUIRED: All customer support calls and chats will be with English Reps. Should you require additional assistance in Spanish please send us an email to info@honeybeepharmacy.com a member of our chat team and email support will send you emails in Spanish.

SHIPPING ADVISORY: Please be advised that due to Covid-19, Canada Post and USPS have both removed their shipping guarantee. Therefore, orders may take 7-10 business days to receive. Please be sure to place your order sooner rather than later. Should you not receive your medication within the quoted time please do not hesitate to give us a call at our toll free number 1 (888) 557-0340 to speak to a member of our customer support team. Thank you.

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Due to Covid-19 both USPS AND CANADA POST have removed their shipping guarantees. Therefore, orders may take 7-10 business days to receive from the date shipped. We ask all new and returning customers to place their orders prior to your own personal supplies running low. Please order ahead of time. We thank you for your cooperation


If you have any questions or would like to speak to a Pharmacist from our contracted Pharmacy department, please do not hesitate to give us a call at our toll free number: 1-888-557-0340.