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Restasis Multidose

Restasis (Cyclosporine Eye Drops)


Restasis (Cyclosporine Eye Drops) is a brand-name prescription drug that’s approved to treat chronic dry eye. It’s prescribed for people ages 16 years and older. With chronic dry eyes, your eyes don’t stay moist like they’re supposed to. (The condition is called “chronic” because it’s long-lasting.) This contains the active drug cyclosporine. It belongs to a class of drugs called calcineurin inhibitor immunosuppression. Restasis works by increasing your eyes’ natural ability to make tears. It is a liquid emulsion (an oily liquid mixture) that’s used as eye drops. It’s available in one strength: 0.5 mg/mL.


Restasis (Cyclosporine Eye Drops) comes as the following two products:

  • Single-use vials. These vials of Restasis can be used for one dose of the drug. Each vial contains 0.4 mL of Restasis.  
  • Restasis MultiDose. These bottles of Restasis can be used for multiple doses of the drug. Each bottle contains 5.5 mL of Restasis. 


Whether you’re using Restasis single-use vials or Restasis MultiDose, you’ll use the drug twice each day by placing drops of the medication into your eyes. Restasis contains the active drug cyclosporine. Restasis eye drops are available only as a brand-name medication. They’re not currently available in a generic form. However, other forms of cyclosporine are available as generic drugs. These forms of cyclosporine are either taken by mouth or given by intravenous (IV) infusion. (An IV infusion is an injection into your vein that’s given over a period of time.) A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be just as safe and effective as the original drug. And generics tend to cost less than brand-name drugs.




You should not use Restasis (Cyclosporine Eye Drops) if you are allergic to cyclosporine. Restasis is likely safe in pregnancy. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Restasis passes into breast milk or if it could harm a nursing baby, although it is likely safe. Tell your doctor if you are breast-feeding a baby. This medicine is not approved for use by anyone younger than 16 years old.




Use this medication in the affected eye(s) as directed by your doctor, usually twice a day (about 12 hours apart). To apply eye drops, wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. There are different brands of this medication available. Some brands should be mixed before use. If your brand does not need to be mixed before use, the liquid is clear and colorless. If your brand should be mixed, evenly mix the eye drops by turning the vial upside down a few times before using your dose. The mixed drops should look milky and white. Ask your doctor or pharmacist if you have any questions about your brand. If you have dry eyes, contact lens wear is usually not recommended. If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out. Try not to blink or rub your eye. If directed to use this medication in both eyes, repeat these steps for your other eye. Do not rinse the dropper. Replace the dropper cap after each use. If you are using another kind of eye medication (such as drops or ointments), wait at least 15 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye. Wait several minutes for your vision to clear before driving or operating machinery. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. If you are using the single-use form of this medication, throw away the opened vial after use. Do not save for later use.  Tell your doctor if your condition gets worse.




Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects: blurred vision, discharge coming out of eyes, dry eyes, eye burning, eye irritation, eye pain, eye redness, eye stinging, feeling of something in the eye, headache, itchy eyes, sensitivity to light. Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. Check with your doctor as soon as possible if any of the following side effects occur: changes in vision, eye swelling, hives. Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication. 




Will I need to use this drug long term?

Restasis (Cyclosporine Eye Drops) is meant to be used as a long-term treatment. If you and your doctor determine that Restasis is safe and effective for you, you’ll likely take it long term.


How long does it take to work?

Depending on how severe your dry eye is, Restasis may take 4 to 6 months to relieve your symptoms. But for some people with mild dry eye, the drug may improve dry eye symptoms within a month. Your eye doctor may recommend a lubricating eye drop for you to use when you first start Restasis treatment. Using a lubricating eye drop can help relieve dry eye symptoms right away while you’re waiting for Restasis to start working. 


The Food and Drug Administration (FDA) approves prescription drugs such as Restasis to treat certain conditions. Restasis may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition. Restasis is FDA-approved to treat chronic dry eye. With this condition, you have inflammation or irritation in your eyes that causes dryness. This often results in stinging, burning, redness, or itching around your eyes. It can also cause difficulty with wearing contact lenses. The condition is called “chronic” because it’s long-lasting. Chronic dry eye results in your body not being able to make enough of your own tears. There are several factors that may contribute to dry eye symptoms, such as: being an older age, environmental conditions, such as smoke, wind, and dry climate, other medical conditions you may have, such as Sjogren’s syndrome. Restasis contains the active drug cyclosporine. It’s thought to work by calming down the inflammation in your eyes and tear ducts. This action helps to improve your body’s natural ability to make tears, which moistens your eyes and reduces dry eye symptoms.  



Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.


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HoneyBee Pharmacy is an established Pharmacy partner located in Canada. HoneyBee Pharmacy puts Americans first by giving Americans the option of buying both brand name and generic medications at affordable prices. Whether it be tablets, capsules, insulin, pet medications – HBP got you covered.HoneyBee Pharmacy is a proud Pharmacy partner that offers the best price guaranteed when it comes to both human and pet medications. If you have any questions or concerns and would like to speak to a member of our contracted Pharmacy department please give us a call at 1-888-557-0340.

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Due to Covid-19 both USPS AND CANADA POST have removed their shipping guarantees. Therefore, orders may take 7-10 business days to receive from the date shipped. We ask all new and returning customers to place their orders prior to your own personal supplies running low. Please order ahead of time. We thank you for your cooperation


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