WHAT IS HUMALOG U-200 KWIKPEN

The Humalog U-200 KwikPen holds 600 units of insulin, compared with 300 units held by the Humalog Kwikpen U-100 formulation, in the same 3-mL cartridge. The newly approved product offers patients a pen that lasts longer between pen changes, which may lead to fewer pen changes per month.

Humalog KwikPen is available in two strengths.The Humalog 200 units/ml KwikPen (and Humalog 100 units/ml KwikPen, see separate SmPC) delivers 1 – 60 units in steps of 1 unit in a single injection. The number of insulin units is shown in the dose window of the pen regardless of strength and no dose conversion should be done when transferring a patient to a new strength or to a pen with a different dose step.

Humalog 200 units/ml KwikPen should be reserved for the treatment of patients with diabetes requiring daily doses of more than 20 units of rapid-acting insulin. The insulin lispro solution containing 200 units/ml should not be withdrawn from the pre-filled pen (the KwikPen) or mixed with any other insulin (see section 4.4 and section 6.2).

USE

For the treatment of adults with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Humalog 200 units/ml KwikPen is also indicated for the initial stabilisation of diabetes mellitus.

Dosage and administration information states the following:

Humalog should be given within 15 minutes before or immediately after a meal.

• Do not administer Humalog U-200 intravenously.
• Do not mix Humalog U-200 in a syringe with any other insulin.
• Do not use Humalog U-200 in a subcutaneous insulin infusion pump.
• Do not perform dose conversion when using either the Humalog U-100 or Humalog U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed.

METHOD OF ADMINISTRATION

Humalog solution for injection should be given subcutaneously.

Subcutaneous administration should be in the upper arms, thighs, buttocks, or abdomen. Use of injection sites should be rotated so that the same site is not used more than approximately once a month., in order to reduce the risk of lipodystrophy and cutaneous amyloidosis (see section 4.4 and 4.8).

When administered subcutaneously care should be taken when injecting Humalog to ensure that a blood vessel has not been entered. After injection, the site of injection should not be massaged. Patients must be educated to use the proper injection techniques. Humalog 200 units/ml KwikPen solution for injection should not be used in an insulin infusion pump.

Humalog 200 units/ml KwikPen solution for injection should not be used intravenously.

HOW TO USE HUMALOG U-200 KWIKPEN

Humalog may be given shortly before meals. When necessary Humalog can be given soon after meals. Humalog takes effect rapidly and has a shorter duration of activity (2 to 5 hours) given subcutaneously as compared with soluble insulin. This rapid onset of activity allows a Humalog injection to be given very close to mealtime. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. The faster onset of action compared to soluble human insulin is maintained regardless of injection site. 

SELECT SAFETY INFORMATION

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

HUMALOG COMMON SIDE EFFECTS

• Throat irritation.
• A stuffy and runny nose.
• Itching.
• Flu-like symptoms.
• Pain.
• Weight gain.
• Headache.
• Cough.

HUMALOG KWIKPEN STORAGE 

Humalog U-200 KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains insulin.

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